一般疾病模型下妨害参数对家庭连锁检验的影响

7th International Symposium on Parallel Architectures, Algorithms and Networks, 2004. Proceedings. Pub Date : 2004-05-10 DOI:10.1109/ISPAN.2004.1300546

Kuang-Chi Chen

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引用次数: 0

摘要

基于家庭的连锁检测是检测疾病遗传基础的方法。对于病例-双亲三联征数据，已知连锁测试会干扰隐性疾病模型下的关联参数。本文的目的是讨论在一般模型下妨害参数对基于家庭的连锁检验的影响。结果表明，在一般模型中，连锁检验不仅会干扰关联参数，还会影响基因替代效应。

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Effects of nuisance parameters on the family-based linkage tests under general disease models

Family-based linkage tests are methods for detection of the genetic basis of a disease. For the case-parent triad data, it is known that tests of linkage interfere with the association parameter under recessive disease models. The purpose of the paper is to discuss the effects of nuisance parameters on the family-based linkage tests under general models. It is shown that the linkage tests do not only interfere with the association parameter, but also with the gene substitution effect in general models.

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7th International Symposium on Parallel Architectures, Algorithms and Networks, 2004. Proceedings.

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