Saranyaraajan Varadarajan, Shahana A Chumki, Rachel E. Stephenson, Eileen Misterovich, Jessica L. Wu, Claire E Dudley, I. Erofeev, A. Goryachev, Ann L. Miller
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Varadarajan et al. find that calcium flashes regulate epithelial barrier function. Using live imaging, optogenetics, and laser-induced tight junction injury, they show that mechanosensitive channel-dependent calcium flashes promote sustained local activation of RhoA, allowing cells to repair tight junction leaks induced by mechanical stimuli.
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