伤口愈合的全新产品

Bong Lee Jae, Keun Cho Seong, So Lim Jong, Soo Kang Kyung
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摘要

蛋壳膜(ESM)已被用作治疗伤口的另一种天然绷带,并可从鸡蛋工业大量获得。本研究是基于利用自然资源进行皮肤组织重建。它需要理解细胞外基质(ECM)的组织再生。创面愈合是一个复杂的、持续的、通过替换功能失调的损伤细胞结构来修复受损组织的过程。创面愈合过程涉及几个不同的阶段:第一阶段为止血,第二阶段为炎症,第三阶段为增殖,最后阶段为成熟/组织重塑。每个过程都需要一个合适的环境来加速愈合。由于皮肤与外界接触,会发生损伤,因此表面经常受伤。由于不同类型的伤口,以及医疗技术的进步,已经开发出各种产品来修复不同的皮肤损伤。我们通过将创面愈合效果分为Exture®组、市售创面敷料组(阳性对照)和未治疗组(阴性对照)来研究伤口愈合效果。我们诱导创面并测量20 d的愈合过程,作为胶原膜创面愈合的比较实验。对于创面,通过血液学分析测量外景照片创面面积的减少、组织内的愈合过程以及免疫反应。我们通过血细胞分析和伤口愈合过程的比较证实了一些差异,但没有发现统计学意义。经处理的胶原蛋白创面敷料膜与市售创面敷料膜无显著差异。因此,本研究揭示了使用基于天然来源的伤口愈合产品的可能性带来了足够的伤口愈合效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Wound healing by brand new product
Eggshell Membrane (ESM) has been used as an alternative natural bandage to cure wounds and is available in large quantities from egg industries. This study is based on the use of natural resources for skin tissue reconstruction. It needs to understand regeneration of tissue with Extracellular Matrix (ECM). Wound healing is a complicated and continuous recovery process of damaged tissues by replacing dysfunctional injured cellular structures. The wound healing process recruits some different phases: the first phase for hemostasis, the second phase for inflammation, the third phase for proliferation, and last phases for maturation/tissue remodeling. Each process needs an appropriate surrounding to achieve accelerated healing. Because the skin is in contact with the outside, injuries occur and therefore the surface is often injured. Due to the different types of wounds, as well as the advancement in medical technology, various products have been developed to repair different skin lesions. We investigate the wound healing effects which are measured by dividing into the Exture® group, the commercially available wound dressing group (positive control), and the untreated group (negative control). We induced wounds and measured the healing process for 20 days for a comparison experiment of collagen membrane wound healing. As for the wound, the decrease in wound area using external photographs, the healing process within the tissue, and the immune response were measured through hematology analysis. We confirmed some differences through comparison of blood cell analysis and wound healing process but did not find statistical significance. There was no significant difference between treated collagen wound dressing film and commercial wound dressing film. Thus, this study reveals that the possibility of use natural source-based wound healing products brings sufficient wound healing results.
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