暴露于uppercott诱导雄性白化wistar大鼠肝毒性

E. Modo, F. Uboh, M. Agiang, E. Ewere
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引用次数: 1

摘要

背景:在农业和为公共卫生目的使用除草剂和杀虫剂对包括人类在内的许多非目标物种造成有害影响。方法:对雄性白化wistar大鼠暴露于氯氰菊酯和乐果混合物(uppercott)后肝脏的影响进行了研究。将45只雄性wistar白化大鼠分为5组,每组9只。1组和2组分别作为正常对照组和油对照组,3组、4组和5组分别给予2.5%、5%和7.5%的上叶草LD 50,口服28 d。结果:结果显示,与对照组相比,各试验组的血清天冬氨酸转氨酶(AST)活性、丙氨酸转氨酶(ALT)活性和碱性磷酸酶(ALP)活性显著升高(p<0.05)。此外,与对照组相比,暴露于上层的人血清胆红素浓度略有升高,但不显著。与对照组相比,所有试验组的超氧化物歧化酶活性均显著降低。肝组织组织学显示,实验组(2.5%、5%和7.5%)肝组织呈斑片状坏死。结论:本研究结果强烈提示紫花苜蓿农药的肝毒性作用,因此,建议谨慎使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exposure to uppercott induces hepatotoxicity in male albino wistar rats
Background: The use of herbicides and pesticides in agriculture and for public health purposes has led to harmful effects in many non-target species including man. Methods: In this study, the hepatic effect of exposure to cypermethrin and dimethoate mixture (uppercott) was investigated in male albino wistar rats. Forty five (45) male wistar albino rats were distributed into five (5) groups of nine (9) animals each. Groups 1 and 2 served as the normal control and oil control respectively, groups 3, 4 and 5 received 2.5%, 5% and 7.5% LD 50 of uppercott orally for 28 days. Results: Results obtained revealed that uppercott exposure significantly (p<0.05) increased serum aspartate aminotransferase (AST) activity, alanine aminotransferase (ALT) activity and alkaline phosphatase (ALP) activity when the test groups were compared with control. Also, uppercott exposure raised serum bilirubin concentration slightly insignificantly compared to the control. Superoxide dismutase activity was significantly reduced across all test groups as compared with compared with control. Histology of liver tissues revealed patchy necrotic sessions in the liver tissues of the test experimental groups (2.5%, 5% and 7.5%). Conclusion: The results obtained from this study are strongly indicative of the hepatotoxic effect of uppercott pesticide and hence, caution during usage is advised.
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