{"title":"衰老免疫系统中基因表达的表观遗传改变","authors":"Dimitrina Miteva, T. Velikova","doi":"10.56543/aaeeu.2023.2.1.05","DOIUrl":null,"url":null,"abstract":"Immunosenescence or aging of the immune system is characterized by dysregulation of the innate and adaptive immune system mechanisms, associated with a systemic low-grade inflammation (i.e., «inflammaging»), non-effective protective humoral and cellular immune responses to a microorgamis or vaccine, autoimmunity, and cancer. In addition, genetic dysregulation and alterations across the immune system drive the cellular manifestations of immunosenescence. In this narrative review, we provide an overview of the recent advancements in immunosenescence research concerning epigenetics alterations in gene regulation and disturbances in gene expression in the aging immune system, focusing on DNA methylation, histone modifications, and microRNAs.","PeriodicalId":437966,"journal":{"name":"Anti-Aging Eastern Europe","volume":"18 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"EPIGENETIC ALTERATIONS IN GENE EXPRESSION IN THE AGING IMMUNE SYSTEM\",\"authors\":\"Dimitrina Miteva, T. Velikova\",\"doi\":\"10.56543/aaeeu.2023.2.1.05\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Immunosenescence or aging of the immune system is characterized by dysregulation of the innate and adaptive immune system mechanisms, associated with a systemic low-grade inflammation (i.e., «inflammaging»), non-effective protective humoral and cellular immune responses to a microorgamis or vaccine, autoimmunity, and cancer. In addition, genetic dysregulation and alterations across the immune system drive the cellular manifestations of immunosenescence. In this narrative review, we provide an overview of the recent advancements in immunosenescence research concerning epigenetics alterations in gene regulation and disturbances in gene expression in the aging immune system, focusing on DNA methylation, histone modifications, and microRNAs.\",\"PeriodicalId\":437966,\"journal\":{\"name\":\"Anti-Aging Eastern Europe\",\"volume\":\"18 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anti-Aging Eastern Europe\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.56543/aaeeu.2023.2.1.05\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anti-Aging Eastern Europe","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56543/aaeeu.2023.2.1.05","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
EPIGENETIC ALTERATIONS IN GENE EXPRESSION IN THE AGING IMMUNE SYSTEM
Immunosenescence or aging of the immune system is characterized by dysregulation of the innate and adaptive immune system mechanisms, associated with a systemic low-grade inflammation (i.e., «inflammaging»), non-effective protective humoral and cellular immune responses to a microorgamis or vaccine, autoimmunity, and cancer. In addition, genetic dysregulation and alterations across the immune system drive the cellular manifestations of immunosenescence. In this narrative review, we provide an overview of the recent advancements in immunosenescence research concerning epigenetics alterations in gene regulation and disturbances in gene expression in the aging immune system, focusing on DNA methylation, histone modifications, and microRNAs.
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