T. Rostami, A. Kiumarsi, Amir Abbas Hedayati Asl, Ashraf Sadat Hoseini,, Asadollah Mousavi
{"title":"异基因造血干细胞移植治疗输注依赖型吡哆醇难治性遗传性铁母细胞贫血1例成功","authors":"T. Rostami, A. Kiumarsi, Amir Abbas Hedayati Asl, Ashraf Sadat Hoseini,, Asadollah Mousavi","doi":"10.15406/htij.2020.08.00211","DOIUrl":null,"url":null,"abstract":"We report a case of pyridoxine refractory, hereditary sideroblastic anaemia (HSA) in a 23 months old girl who underwent bone marrow stem cell transplantation (BMSCT) from his 28-year-old HLA‐identical maternal uncle. By using short tandem repeat polymorphism, 95% donor cells were observed in peripheral blood on day +15, +30, +90 and until the present time; the patient did not develop any significant graft‐versus‐host disease or other transplant complications. One year after transplantation, the patient has a Lansky score1 of 100, with a normal cell blood count (CBC).","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"177 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Successful allogeneic hematopoietic stem cell transplantation in a child with transfusion-dependent pyridoxine refractory hereditary sideroblastic anaemia\",\"authors\":\"T. Rostami, A. Kiumarsi, Amir Abbas Hedayati Asl, Ashraf Sadat Hoseini,, Asadollah Mousavi\",\"doi\":\"10.15406/htij.2020.08.00211\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We report a case of pyridoxine refractory, hereditary sideroblastic anaemia (HSA) in a 23 months old girl who underwent bone marrow stem cell transplantation (BMSCT) from his 28-year-old HLA‐identical maternal uncle. By using short tandem repeat polymorphism, 95% donor cells were observed in peripheral blood on day +15, +30, +90 and until the present time; the patient did not develop any significant graft‐versus‐host disease or other transplant complications. One year after transplantation, the patient has a Lansky score1 of 100, with a normal cell blood count (CBC).\",\"PeriodicalId\":103294,\"journal\":{\"name\":\"Hematology & Transfusion International Journal\",\"volume\":\"177 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hematology & Transfusion International Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/htij.2020.08.00211\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hematology & Transfusion International Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/htij.2020.08.00211","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Successful allogeneic hematopoietic stem cell transplantation in a child with transfusion-dependent pyridoxine refractory hereditary sideroblastic anaemia
We report a case of pyridoxine refractory, hereditary sideroblastic anaemia (HSA) in a 23 months old girl who underwent bone marrow stem cell transplantation (BMSCT) from his 28-year-old HLA‐identical maternal uncle. By using short tandem repeat polymorphism, 95% donor cells were observed in peripheral blood on day +15, +30, +90 and until the present time; the patient did not develop any significant graft‐versus‐host disease or other transplant complications. One year after transplantation, the patient has a Lansky score1 of 100, with a normal cell blood count (CBC).
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