明胶浓度对复合骨支架孔隙和膨胀行为的影响

Mehdi Jalili AhmadAbad, Mohammad Bakhshi Beris, N. Kiaie
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引用次数: 1

摘要

复合材料作为药物传递模板和细胞支架在生物医学工程中有着广泛的应用。本研究采用冷冻干燥法制备了壳聚糖-明胶- tcp复合支架,考察了明胶浓度对支架孔隙率和溶胀率的影响。通过扫描电镜观察支架的形态和孔隙率。用红外光谱分析了复合材料中元素的结合,并用PBS进行了溶胀试验。结果表明,明胶用量与支架的孔径、孔隙率和溶胀率之间存在直接关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of gelatin concentration on pores and swelling behaviour of a composite bone scaffold
composites have a wide range of applications in biomedical engineering as drug delivery templates and cell scaffolds. In this study, a composite scaffold of Chitosan-Gelatin-TCP was fabricated through freeze drying method and effect of gelatin concentration on porosity and swelling of scaffolds was investigated. Morphology and porosity of scaffolds was assessed by SEM. Binding of elements in composite was shown by FTIR and swelling test was performed in PBS. The results showed there exist a direct relationship between amount of gelatin in scaffold, pore size, porosity, and swelling ratio.
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