A Case of Secondary Syphilis with Inflammation of Oral Mucosa

： We experienced a case of secondary syphilis with inflammation of the oral mucosa. The patient was a 24-year-old woman who was referred to our department with chief complaints of healing failure of stomatitis in the oral cavity. Ulcers were found in the tongue and palate, and findings of angina were observed. Both the qualitative and quantitative values of TPHA and RPR were positive. Biopsy from the palate showed positive immunohistochemical staining with anti Treponema pallidam antibody. Flat condyloma was also recognized and diagnosed as secondary syphilis. Ampicillin was administered and the lesion disappeared. Because syphilis is preceded by oral lesions, early detection is important.