双溴调醇(NSC-104800)与环磷酰胺(NSC-26271)作为既往治疗的急性淋巴细胞白血病或急性未分化白血病儿童缓解维持疗法的比较:降低中枢神经系统白血病发病率的可能有效性

Cancer chemotherapy reports Pub Date : 1975-09-01
A L Sitarz, V Albo, N Movassaghi, M Karon, D Hammond, J Weiner, A Reed
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引用次数: 0

摘要

二溴调醇和环磷酰胺都是烷基化剂。在这项研究中,比较了这两种药物作为儿童急性淋巴细胞白血病或急性未分化白血病缓解维持治疗的有效性。两组患者的毒性作用相似,但双溴调醇治疗未发生膀胱炎。二溴调醇组的缓解时间略短于环磷酰胺组(P = 0.04)。然而,在接受二溴调醇治疗的患者中,中枢神经系统白血病的发病率较低,这似乎与患者组之间的基本差异无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dibromodulcitol (NSC-104800) compared with cyclophosphamide (NSC-26271) as remission maintenance therapy in previously treated children with acute lymphoblastic leukemia or acute undifferentiated leukemia: possible effectiveness in reducing the incidence of central nervous system leukemia.

Dibromodulcitol and cyclophosphamide are both alkylating agents. In this study, these two drugs were compared for their effectiveness as remission maintenance therapy for childhood acute lymphoblastic leukemia or acute undifferentiated leukemia. Toxic effects were similar in both groups of patients although cystitis did not occur with the dibromodulcitol treatment. The duration of remission was slightly shorter for dibromodulcitol than for cyclophosphamide (P = 0.04). There was, however, a lower incidence of CNS leukemia in the patients treated with dibromodulcitol, which did not seem to be related to a basic difference in the patient groups.

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