{"title":"使用加速氦离子的相对生物学效果随肿瘤大小的变化。","authors":"J Shaeffer, A M El-Mahdi, H Aceto, W C Constable","doi":"10.3109/02841867609131960","DOIUrl":null,"url":null,"abstract":"<p><p>The RBE of an accelerated helium ion beam was determined on murine osteosarcomas ranging in size from single cells to visibly detectable lung colonies of approximately 1 X 10(-2) mm3. That the RBE increased as tumor size increased provides some biologic basis for the selection of advanced cases of neoplasia for clinical trials using relatively high LET radiation sources.</p>","PeriodicalId":7139,"journal":{"name":"Acta radiologica: therapy, physics, biology","volume":"15 3","pages":"233-40"},"PeriodicalIF":0.0000,"publicationDate":"1976-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841867609131960","citationCount":"3","resultStr":"{\"title\":\"Variation of the relative biologic effectiveness with tumor size using accelerated helium ions.\",\"authors\":\"J Shaeffer, A M El-Mahdi, H Aceto, W C Constable\",\"doi\":\"10.3109/02841867609131960\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The RBE of an accelerated helium ion beam was determined on murine osteosarcomas ranging in size from single cells to visibly detectable lung colonies of approximately 1 X 10(-2) mm3. That the RBE increased as tumor size increased provides some biologic basis for the selection of advanced cases of neoplasia for clinical trials using relatively high LET radiation sources.</p>\",\"PeriodicalId\":7139,\"journal\":{\"name\":\"Acta radiologica: therapy, physics, biology\",\"volume\":\"15 3\",\"pages\":\"233-40\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/02841867609131960\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta radiologica: therapy, physics, biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/02841867609131960\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta radiologica: therapy, physics, biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/02841867609131960","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Variation of the relative biologic effectiveness with tumor size using accelerated helium ions.
The RBE of an accelerated helium ion beam was determined on murine osteosarcomas ranging in size from single cells to visibly detectable lung colonies of approximately 1 X 10(-2) mm3. That the RBE increased as tumor size increased provides some biologic basis for the selection of advanced cases of neoplasia for clinical trials using relatively high LET radiation sources.
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