INFLUENCE OF INDUSTRIAL VIBRATION ON MINERAL METABOLISM, ORGANS OF THE ORAL CAVITY AND FETAL MYOCARDIUM

In the study, the morphometric analysis of bone trabeculae of the developing jaws, tooth buds, tongue muscles, masseter muscle, and myocardium of 20-day fetuses of Wistar rats, exposed to vibration from the 9th to the 18th day of prenatal ontogenesis, was performed. The concentration of Ca, Cd, Cu, Fe, Mg, P, Pb, Se, Zn was determined in the liver of pregnant females exposed to vibration. The morphometric study revealed an acceleration of the osteogenesis of jaws and dentinogenesis of tooth buds. In the myocardium and masseter muscle signs of interstitial edema and a decrease in the area of the vessels of the microvasculature are determined. In the liver, there is a decrease in the amount of Ca, Mg and Fe, which is accompanied by an increase in the content of Cd and Pb. The revealed shifts in mineral metabolism indicate gross impairment of chemicals' homeostasis in the mother-fetus system, which underlies the imperfect morphogenesis of the fetal dentition and will be the basis for the formation of pathology of orofacial organs and cardiovascular pathology in offspring.