β 2-微球蛋白淀粉样变引起腕管综合征,模拟偷窃综合征

O. Mohamed, M. Taher, Walyeldin Elfakey
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引用次数: 0

摘要

正常的肾脏过滤和清除血液中多余的小蛋白质;从而保持血液水平正常。当肾脏衰竭时,就像接受透析的病人一样,一种叫做β 2微球蛋白的小蛋白质会在血液中积聚。当这种情况发生时,β 2-微球蛋白分子可能会像链环一样连接在一起,由许多较小的分子形成几个非常大的分子。这些大分子会形成沉积物,最终损害周围组织,引起极大的不适。这种情况被称为透析相关性淀粉样变性(DRA)
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Beta 2-microglobulin amyloidosis causing carpal tunnel syndrome, mimic steal syndrome
Normal kidneys filter and remove excess small proteins from the blood; thus, keeping blood levels normal. When the kidneys failed, as in patients receiving dialysis, one type of small protein called beta 2-microglobulin builds up in the blood. When this occurs, beta 2-microglobulin molecules may join together, like the links of a chain, forming a few very large molecules from many smaller ones. These large molecules can form deposits and eventually damage the surrounding tissues and cause great discomfort. This condition is called dialysis-related amyloidosis (DRA).1
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