W J Serfontein, L S de Villiere, L S Villiers, D Botha
{"title":"对乙酰氨基酚和d-丙氧酚的GLC测定。","authors":"W J Serfontein, L S de Villiere, L S Villiers, D Botha","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>d-Propoxyphene and d-norpropoxyphene were determined in rat plasms, rat brain homogenates and human plasma by means of GLC utilizing extracts obtained by micro-phase extraction of the drugs. Paracetamol was determined in the same samples by GLC separation of the O-butyrate derivative using caffeine as internal standard. The problems associated with the GLC determination of d-propoxyphene and d-norpropoxyphene in biological material are discussed and attention is drawn to the particular advantages of the micro-phase extraction procedure for the quantitative determination of these drugs.</p>","PeriodicalId":22995,"journal":{"name":"The South African journal of medical sciences","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"GLC determination of paracetamol and d-propoxyphene.\",\"authors\":\"W J Serfontein, L S de Villiere, L S Villiers, D Botha\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>d-Propoxyphene and d-norpropoxyphene were determined in rat plasms, rat brain homogenates and human plasma by means of GLC utilizing extracts obtained by micro-phase extraction of the drugs. Paracetamol was determined in the same samples by GLC separation of the O-butyrate derivative using caffeine as internal standard. The problems associated with the GLC determination of d-propoxyphene and d-norpropoxyphene in biological material are discussed and attention is drawn to the particular advantages of the micro-phase extraction procedure for the quantitative determination of these drugs.</p>\",\"PeriodicalId\":22995,\"journal\":{\"name\":\"The South African journal of medical sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The South African journal of medical sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The South African journal of medical sciences","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
GLC determination of paracetamol and d-propoxyphene.
d-Propoxyphene and d-norpropoxyphene were determined in rat plasms, rat brain homogenates and human plasma by means of GLC utilizing extracts obtained by micro-phase extraction of the drugs. Paracetamol was determined in the same samples by GLC separation of the O-butyrate derivative using caffeine as internal standard. The problems associated with the GLC determination of d-propoxyphene and d-norpropoxyphene in biological material are discussed and attention is drawn to the particular advantages of the micro-phase extraction procedure for the quantitative determination of these drugs.
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