{"title":"covid-19急性后后遗症。病理生理学、风险、生物标志物、诊断和预后","authors":"L. Mukhomorova, V. V. Velkov","doi":"10.14489/lcmp.2022.03.pp.057-064","DOIUrl":null,"url":null,"abstract":"The paper refers the outcomes of international research in post-acute sequelae of COVID-19 (PASC). It is necessary to emphasize the pathophysiological mechanisms of PASC in PCR-negative patients recovered from COVID-19: long-persistent hyperactivated congenital immunity, hyper-inflammation, hyper-coagulation, hypo-fibrinolysis, micro-thrombosis, antibodies formation, and multiplе human organ dysfunction. The challenges as well as possibilities in laboratory diagnostics of PASC complication have been noted.","PeriodicalId":287737,"journal":{"name":"Laboratornaya i klinicheskaya meditsina. Farmatsiya","volume":"7 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"POST-ACUTE SEQUELAE OF COVID-19. THE PATHOPHYSIOLOGY, RISKS, BIOMARKERS, DIAGNOSIS, AND PROGNOSIS\",\"authors\":\"L. Mukhomorova, V. V. Velkov\",\"doi\":\"10.14489/lcmp.2022.03.pp.057-064\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The paper refers the outcomes of international research in post-acute sequelae of COVID-19 (PASC). It is necessary to emphasize the pathophysiological mechanisms of PASC in PCR-negative patients recovered from COVID-19: long-persistent hyperactivated congenital immunity, hyper-inflammation, hyper-coagulation, hypo-fibrinolysis, micro-thrombosis, antibodies formation, and multiplе human organ dysfunction. The challenges as well as possibilities in laboratory diagnostics of PASC complication have been noted.\",\"PeriodicalId\":287737,\"journal\":{\"name\":\"Laboratornaya i klinicheskaya meditsina. Farmatsiya\",\"volume\":\"7 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Laboratornaya i klinicheskaya meditsina. Farmatsiya\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14489/lcmp.2022.03.pp.057-064\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratornaya i klinicheskaya meditsina. Farmatsiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14489/lcmp.2022.03.pp.057-064","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
POST-ACUTE SEQUELAE OF COVID-19. THE PATHOPHYSIOLOGY, RISKS, BIOMARKERS, DIAGNOSIS, AND PROGNOSIS
The paper refers the outcomes of international research in post-acute sequelae of COVID-19 (PASC). It is necessary to emphasize the pathophysiological mechanisms of PASC in PCR-negative patients recovered from COVID-19: long-persistent hyperactivated congenital immunity, hyper-inflammation, hyper-coagulation, hypo-fibrinolysis, micro-thrombosis, antibodies formation, and multiplе human organ dysfunction. The challenges as well as possibilities in laboratory diagnostics of PASC complication have been noted.
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