疏连健脾颗粒乙醇提取工艺的Box-Behnken设计优化

Yingying Wang, Guang-Jiao Zhou, Xiao-Wei Li
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引用次数: 0

摘要

目的:优选泻连健脾颗粒的提取工艺。方法:采用box-Behnken响应面法对泻连健脾颗粒的提取工艺进行优化,并根据提取液中京尼平苷的含量和提取液得率进行综合评分。结果:最佳提取工艺为:加水量10倍,煮2次,每次煮3h。在此条件下,综合得分为96.816。验证试验的综合评分为99.07(RSD=0.54%, n=3),结果基本一致。结论:该工艺稳定可行,可为泻连健脾颗粒的制备提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Box-Behnken Designs for the Optimization of the Ethanol Extraction Process for Chuilian Jianpi Granules
Objective: The extraction process of Chuilian Jianpi granules was optimized.Methods: The extraction process of Chuilian Jianpi granules was optimized by box-Behnken response surface method, and the comprehensive score was calculated based on the content of geniposide in the extract and the yield of extract.Results: The optimal extraction process was as follows: add water volume multiple of 10 times, cook twice, cook for 3h each time. Under this condition, the comprehensive score was 96.816. The comprehensive score of the validation test was 99.07(RSD=0.54%, n=3), and the results were basically consistent.Conclusion: The process is stable and feasible, which can provide basis for the preparation of Chuilian Jianpi granules.
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