绒毛膜对琥珀酰胆碱的渗透性。

B C Eichhorst, A E Seeds
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引用次数: 1

摘要

测定了14c -琥珀酰胆碱和对氨基马粪酸在体外人胎盘组织中的同时扩散。柱层析纯化后的纸层析分析表明,在实验过程中琥珀酰胆碱的变化不大。测量了两种溶质的氯仿缓冲分配系数。因此,在这些实验中,这两种大小相似的脂不溶性化合物几乎相同的转移速率表明,琥珀酰胆碱穿过人胎盘组织的数量与其分子大小和疏脂性相适应,并且扩散速率不受其分子电荷增加的显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Permeability of chorion laeve to succinylcholine in vitro.

The simultaneous diffusion of 14C-succinylcholine and p-amino hippurate across human placental tissue in vitro was measured. Column chromatographic purification of the radioactivity followed by paper chromatographic analysis showed little alteration of the succinylcholine during the course of these experiments. Similar chloroform-buffer partition coefficients for the two solutes were measured. Thus in these experiments, the nearly identical transfer rates of these two similar sized, lipid-insoluble compounds indicated that succinylcholine crosses human placental tissue in quantitites compatible with its molecular size and lipophobic nature, and that the diffusion rate is not significantly influenced by its increased molecular charge.

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