{"title":"功能化MCM-48作为活性生物分子l -精氨酸体外控释的载体","authors":"Anjali U. Patel, P. Solanki","doi":"10.5772/intechopen.90175","DOIUrl":null,"url":null,"abstract":"The present chapter describes the synthesis, characterizations, and application of MCM-48 functionalized by an inorganic moiety, as a carrier. MCM-48 functionalized by 12-tungstophophoric acid (TPA) (TPA-MCM-48) and L-arginine was loaded into pure as well as functionalized MCM-48. Both the materials were characterized by various physicochemical techniques and evaluated for in vitro release of L-arginine at body temperature under different conditions. A study on release kinetics was carried out using first-order release kinetic model, while the mechanism were by Higuchi model. Further, to see the influence of TPA on release rate, release profile obtained from pure and functionalized MCM-48 was compared.","PeriodicalId":170017,"journal":{"name":"Advances in Microporous and Mesoporous Materials","volume":"10 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Functionalized MCM-48 as Carrier for In Vitro Controlled Release of an Active Biomolecule, L-Arginine\",\"authors\":\"Anjali U. Patel, P. Solanki\",\"doi\":\"10.5772/intechopen.90175\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present chapter describes the synthesis, characterizations, and application of MCM-48 functionalized by an inorganic moiety, as a carrier. MCM-48 functionalized by 12-tungstophophoric acid (TPA) (TPA-MCM-48) and L-arginine was loaded into pure as well as functionalized MCM-48. Both the materials were characterized by various physicochemical techniques and evaluated for in vitro release of L-arginine at body temperature under different conditions. A study on release kinetics was carried out using first-order release kinetic model, while the mechanism were by Higuchi model. Further, to see the influence of TPA on release rate, release profile obtained from pure and functionalized MCM-48 was compared.\",\"PeriodicalId\":170017,\"journal\":{\"name\":\"Advances in Microporous and Mesoporous Materials\",\"volume\":\"10 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Microporous and Mesoporous Materials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5772/intechopen.90175\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Microporous and Mesoporous Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5772/intechopen.90175","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Functionalized MCM-48 as Carrier for In Vitro Controlled Release of an Active Biomolecule, L-Arginine
The present chapter describes the synthesis, characterizations, and application of MCM-48 functionalized by an inorganic moiety, as a carrier. MCM-48 functionalized by 12-tungstophophoric acid (TPA) (TPA-MCM-48) and L-arginine was loaded into pure as well as functionalized MCM-48. Both the materials were characterized by various physicochemical techniques and evaluated for in vitro release of L-arginine at body temperature under different conditions. A study on release kinetics was carried out using first-order release kinetic model, while the mechanism were by Higuchi model. Further, to see the influence of TPA on release rate, release profile obtained from pure and functionalized MCM-48 was compared.
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