多个线圈在传导液体中用于深部和全脑经颅磁刺激。一、单频激励

H. Oliveira, M. Dias Silva, C. V. Ferreira, P. Fonte, L. Jesus, R. Salvador, J. Silvestre, P. Crespo
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引用次数: 1

摘要

我们提出了一个由多个线圈组成的系统,这些线圈以单一频率激发,浸入导电液体中,允许前所未有的深度,全脑经颅磁刺激(TMS)。将有限元方法应用于球体头部模型和椭球躯干模型。头部模型包括皮肤、颅骨、脑脊液和脑组织。结果表明,深层脑感应电流在穿透10 cm处(脑中心)相对于表面(皮层)最大达到85%。相比之下,最新公布的数据仅在8厘米深度处达到47%的相对感应。通过将刺激线圈(以及部分患者头部)浸入导电液体(如电解质溶液或液态金属)中,该系统与众所周知的限制效应相对应,这种限制效应是由于大脑/表面界面电流密度的增强而产生的。此外,几个系统的不对称性被利用,以优化深层脑刺激到大脑的中心。虽然在视网膜和躯干中诱导的电流密度估计达到了患者安全的次优水平,但这些初步的积极结果表明克服脑/表面感应屏障是可行的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multiple coils in a conducting liquid for deep and whole-brain transcranial magnetic stimulation. I. Single-frequency excitation
We present a system comprising multiple coils excited at a single frequency and immersed in a conducting liquid allowing for unprecedented deep, whole-brain transcranial magnetic stimulation (TMS). Finite-element methods were applied onto a spherical head model complemented by an ellipsoidal torso. The head model comprises skin, skull, cerebral spinal fluid, and brain tissue. Results show deep-brain induced currents reaching 85% at 10-cm penetration (brain center) in respect to surface (cortex) maximum. For comparison, state-of-the-art published data reach 47% relative induction at 8-cm depth only. This system counterparts well-known limiting effects occurring due to the enhancement of current densities at the brain/surface interface by immersing the stimulating coils (and partially the head of the patient) into a conducting liquid such as an electrolyte solution or a liquid metal. In addition, several system asymmetries are exploited in order to optimize deep-brain stimulation down to the center of the brain. Although current densities induced in the retinas and in the torso are estimated to reach sub-optimum levels in regard to patient safety, these first positive results show that overcoming the brain/surface induction barrier is feasible.
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