聚乙二醇40%与无花果糖浆治疗儿童慢性功能性便秘的疗效比较:一项随机临床试验

Narges Maleki, K. Kasiri, Mohammad Reza Malek-Ahmadi, F. Deris
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引用次数: 0

摘要

背景和目的:目前没有一种治疗儿童便秘的方法是完全成功的。因此,本研究旨在评价40%聚乙二醇(PEG)溶液与无花果糖浆治疗儿童慢性便秘的效果。方法:选择120例慢性功能性便秘患者进行双盲临床试验,随机分为两组。第一组给予不含番泻叶的无花果糖浆5 mL,每日3次;第二组给予PEG 40%糖浆,每日1 mL/kg体重(剂量可根据患者情况和需要调整)。在第0、2、4、6周,研究者填写儿童便秘问题清单,并使用SPSS version 24对数据进行分析。结果:两组患者第0、2、4、6周第4次腹痛频次变化差异均有统计学意义(P=0.044), PEG组明显降低;排便量差异无统计学意义(P=0.902)。6周后,与无花果糖浆组相比,PEG糖浆组的排便疼痛、排便困难、排便紧张的频率显著降低(P=0.001)。结论:总体而言,与无花果糖浆相比,聚乙二醇糖浆对儿童慢性功能性便秘有显著疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the effect of polyethylene glycol 40% and fig syrups on the treatment of chronic functional constipation in children: A randomized clinical trial
Background and aims: None of the available constipation treatments for children are completely successful. Therefore, the present study aimed to evaluate the effect of the polyethylene glycol (PEG) solution 40% and fig syrup on the treatment of chronic constipation in children. Methods: In this double-blind clinical trial, 120 patients with chronic functional constipation were selected and divided into two groups. The first group received 5 mL of fig syrup without senna 3 times daily, and the second group took PEG 40% syrup at 1 mL/kg of body weight per day (the dose was adjustable according to the patient’s condition and need). At weeks 0, 2, 4, and 6, a checklist containing questions about children’s constipation was completed by the researcher, and the data were analyzed by SPSS version 24. Results: Changes in the frequency of abdominal pain at fourth times 0, 2, 4, and 6 weeks demonstrated statistically significant differences between the two groups (P=0.044), and it was significantly lower the in PEG group; however, the defecation was not statistically significant (P=0.902). After six weeks, the frequency of painful defecation, difficult defecation straining during defecation, and fear of defecation was significantly lower in the group given PEG syrup compared to the fig syrup-receiving group (P=0.001). Conclusion: Overall, PEG syrup was significantly effective in treating chronic functional constipation in children compared to the fig syrup.
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