Suitable Effective Mode of Administration of Intravenous Ara-C in Acute Leukaemias

Abstract: Ara-c is a commonly used drug in acute leukaemias. In different stages of treatment dose and mode of administration of this drug is variable. It is usually considered as a cell cycle specific drug, but except in ‘standard’ induction of remission therapy for acute myelogenous leukaemia it is not usually given by continuous infusion in other conditions. This article discusses about the different intravenous modes of administration of ara-c in AML induction chemotherapy, their outcomes, and urges for trials to find out a suitable mode of administration of this common drug. Keywords: cytosine arabinoside, arabinocytosar, arabinosyl cytarabine, ara-c, cytarabine