{"title":"人砷膳食摄入与地方性慢性中毒的生态学调查:剂量-反应曲线。","authors":"R Zaldívar","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The city of Antofagasta (northern Chile), is an area of endemic chronic arsenic poisoning due to arsenic-polluted drinking water. In order to explore the possibility of a dose-response relationship, a dietary survey was carried out in 1972 in that city for measuring the daily fluid intake in the various age groups. The sample (N = 220) included 13 males and 13 females in each age group, except the 81-90 year-old group with 6 males and 6 females. A linear relationship was found between arsenic dose (mg/kg body weight/day) and age for males being P less than 0.001 (slope) and r = -0.6712; and for females P less than 0.001 (slope) and r = 0.6667. Age-specific prevalence rates per 100,000 population (both sexes combined) for chronic arsenic poisoning in Antofagasta Commune for the 1968-71 period, were plotted against mean arsenic doses (mg/kg body weight/day) by age group. A dose-response curve was computed, being F = 83.19, d.f. = 1,7 and P less than 0.01 (slope). The correlation coefficient was + 0.9604.</p>","PeriodicalId":76868,"journal":{"name":"Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin","volume":"164 5-6","pages":"481-4"},"PeriodicalIF":0.0000,"publicationDate":"1977-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ecological investigations on arsenic dietary intake and endemic chronic poisoning in man: dose-response curve.\",\"authors\":\"R Zaldívar\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The city of Antofagasta (northern Chile), is an area of endemic chronic arsenic poisoning due to arsenic-polluted drinking water. In order to explore the possibility of a dose-response relationship, a dietary survey was carried out in 1972 in that city for measuring the daily fluid intake in the various age groups. The sample (N = 220) included 13 males and 13 females in each age group, except the 81-90 year-old group with 6 males and 6 females. A linear relationship was found between arsenic dose (mg/kg body weight/day) and age for males being P less than 0.001 (slope) and r = -0.6712; and for females P less than 0.001 (slope) and r = 0.6667. Age-specific prevalence rates per 100,000 population (both sexes combined) for chronic arsenic poisoning in Antofagasta Commune for the 1968-71 period, were plotted against mean arsenic doses (mg/kg body weight/day) by age group. A dose-response curve was computed, being F = 83.19, d.f. = 1,7 and P less than 0.01 (slope). The correlation coefficient was + 0.9604.</p>\",\"PeriodicalId\":76868,\"journal\":{\"name\":\"Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin\",\"volume\":\"164 5-6\",\"pages\":\"481-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1977-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, praventive Medizin","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Ecological investigations on arsenic dietary intake and endemic chronic poisoning in man: dose-response curve.
The city of Antofagasta (northern Chile), is an area of endemic chronic arsenic poisoning due to arsenic-polluted drinking water. In order to explore the possibility of a dose-response relationship, a dietary survey was carried out in 1972 in that city for measuring the daily fluid intake in the various age groups. The sample (N = 220) included 13 males and 13 females in each age group, except the 81-90 year-old group with 6 males and 6 females. A linear relationship was found between arsenic dose (mg/kg body weight/day) and age for males being P less than 0.001 (slope) and r = -0.6712; and for females P less than 0.001 (slope) and r = 0.6667. Age-specific prevalence rates per 100,000 population (both sexes combined) for chronic arsenic poisoning in Antofagasta Commune for the 1968-71 period, were plotted against mean arsenic doses (mg/kg body weight/day) by age group. A dose-response curve was computed, being F = 83.19, d.f. = 1,7 and P less than 0.01 (slope). The correlation coefficient was + 0.9604.
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