{"title":"临床相关照射对胸腺裸鼠生长的人恶性黑色素瘤的影响。","authors":"E K Rofstad, T Brustad, J V Johannessen","doi":"10.3109/02841867709133947","DOIUrl":null,"url":null,"abstract":"<p><p>Human tumors grown subcutaneously in the thymus deficient nude mice are used as a model system to compare the effectiveness of clinically relevant irradiation regimes. Procedures for local irradiation of the tumors with 60Co radiation are described in detail. A preliminary test of the regression of two malignant melanomas, following three clinically relevant fractionation schedules, is performed. The overall treatment time and the nominal standard dose (NSD) are kept equal for the irradiation regimes chosen.</p>","PeriodicalId":7139,"journal":{"name":"Acta radiologica: therapy, physics, biology","volume":"16 3","pages":"273-80"},"PeriodicalIF":0.0000,"publicationDate":"1977-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/02841867709133947","citationCount":"9","resultStr":"{\"title\":\"Effect of clinically relevant irradiation regimes on human malignant melanomas grown in athymic nude mice.\",\"authors\":\"E K Rofstad, T Brustad, J V Johannessen\",\"doi\":\"10.3109/02841867709133947\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Human tumors grown subcutaneously in the thymus deficient nude mice are used as a model system to compare the effectiveness of clinically relevant irradiation regimes. Procedures for local irradiation of the tumors with 60Co radiation are described in detail. A preliminary test of the regression of two malignant melanomas, following three clinically relevant fractionation schedules, is performed. The overall treatment time and the nominal standard dose (NSD) are kept equal for the irradiation regimes chosen.</p>\",\"PeriodicalId\":7139,\"journal\":{\"name\":\"Acta radiologica: therapy, physics, biology\",\"volume\":\"16 3\",\"pages\":\"273-80\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1977-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3109/02841867709133947\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta radiologica: therapy, physics, biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3109/02841867709133947\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta radiologica: therapy, physics, biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/02841867709133947","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of clinically relevant irradiation regimes on human malignant melanomas grown in athymic nude mice.
Human tumors grown subcutaneously in the thymus deficient nude mice are used as a model system to compare the effectiveness of clinically relevant irradiation regimes. Procedures for local irradiation of the tumors with 60Co radiation are described in detail. A preliminary test of the regression of two malignant melanomas, following three clinically relevant fractionation schedules, is performed. The overall treatment time and the nominal standard dose (NSD) are kept equal for the irradiation regimes chosen.
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