{"title":"IgE和IgE抗体的放射免疫测定及其临床应用。","authors":"S G Johansson","doi":"10.1136/jcp.s1-6.1.33","DOIUrl":null,"url":null,"abstract":"For more than 50 years it has been known that some patients with asthma, allergic rhinitis and eczema possess antibodies with skin-sensitizing properties, so-called reagins. It is now well established that the reagins belong to a unique immunoglobulin class, IgE (Ishizaka and Ishizaka, 1967; Johansson and Bennich, 1967). The isolation of IgE and the raising of antibodies against IgE made possible the development of immunological assays for IgE and allergenspecific IgE antibody. The aim of this paper is to discuss the methodological aspects of the determination of IgE and IgE antibody as well as their clinical application.","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"6 ","pages":"33-7"},"PeriodicalIF":0.0000,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-6.1.33","citationCount":"11","resultStr":"{\"title\":\"Radioimmunoassay of IgE and IgE antibody and its clinical application.\",\"authors\":\"S G Johansson\",\"doi\":\"10.1136/jcp.s1-6.1.33\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"For more than 50 years it has been known that some patients with asthma, allergic rhinitis and eczema possess antibodies with skin-sensitizing properties, so-called reagins. It is now well established that the reagins belong to a unique immunoglobulin class, IgE (Ishizaka and Ishizaka, 1967; Johansson and Bennich, 1967). The isolation of IgE and the raising of antibodies against IgE made possible the development of immunological assays for IgE and allergenspecific IgE antibody. The aim of this paper is to discuss the methodological aspects of the determination of IgE and IgE antibody as well as their clinical application.\",\"PeriodicalId\":75995,\"journal\":{\"name\":\"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)\",\"volume\":\"6 \",\"pages\":\"33-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1136/jcp.s1-6.1.33\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/jcp.s1-6.1.33\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/jcp.s1-6.1.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Radioimmunoassay of IgE and IgE antibody and its clinical application.
For more than 50 years it has been known that some patients with asthma, allergic rhinitis and eczema possess antibodies with skin-sensitizing properties, so-called reagins. It is now well established that the reagins belong to a unique immunoglobulin class, IgE (Ishizaka and Ishizaka, 1967; Johansson and Bennich, 1967). The isolation of IgE and the raising of antibodies against IgE made possible the development of immunological assays for IgE and allergenspecific IgE antibody. The aim of this paper is to discuss the methodological aspects of the determination of IgE and IgE antibody as well as their clinical application.
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