{"title":"品多洛尔与肼嗪联合治疗原发性高血压。","authors":"I Persson","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Thirty patients suffering from essential hypertension were treated successively with placebo, hydralazine alone, and pindolol (Viskén) combined with hydralazine. As compared to placebo hydralazine brought about a statistically significant reduction in blood pressure and an increase in pulse rate; palpitation was an irritating side-effect. Combining hydralazine and pindolol caused an additional fall in blood pressure (2 p less than 0.001) and the pulse rate decreased (2 p less than 0.001). This combination treatment had a favourable effect on the palpitation and angina pectoris also.</p>","PeriodicalId":75437,"journal":{"name":"Advances in clinical pharmacology","volume":"11 ","pages":"1114-8"},"PeriodicalIF":0.0000,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Combination therapy of essential hypertension with pindolol (Visken) and hydralazine.\",\"authors\":\"I Persson\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Thirty patients suffering from essential hypertension were treated successively with placebo, hydralazine alone, and pindolol (Viskén) combined with hydralazine. As compared to placebo hydralazine brought about a statistically significant reduction in blood pressure and an increase in pulse rate; palpitation was an irritating side-effect. Combining hydralazine and pindolol caused an additional fall in blood pressure (2 p less than 0.001) and the pulse rate decreased (2 p less than 0.001). This combination treatment had a favourable effect on the palpitation and angina pectoris also.</p>\",\"PeriodicalId\":75437,\"journal\":{\"name\":\"Advances in clinical pharmacology\",\"volume\":\"11 \",\"pages\":\"1114-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1976-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in clinical pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in clinical pharmacology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
对30例原发性高血压患者分别采用安慰剂、单药肼、品多洛尔(visksamuin)联合肼治疗。与安慰剂相比，海拉嗪能显著降低血压，增加脉搏率;心悸是一种令人恼火的副作用。联合使用肼嗪和品多洛可使血压进一步下降(2 p < 0.001)，脉搏率下降(2 p < 0.001)。联合用药对心悸、心绞痛也有较好的治疗效果。
Combination therapy of essential hypertension with pindolol (Visken) and hydralazine.
Thirty patients suffering from essential hypertension were treated successively with placebo, hydralazine alone, and pindolol (Viskén) combined with hydralazine. As compared to placebo hydralazine brought about a statistically significant reduction in blood pressure and an increase in pulse rate; palpitation was an irritating side-effect. Combining hydralazine and pindolol caused an additional fall in blood pressure (2 p less than 0.001) and the pulse rate decreased (2 p less than 0.001). This combination treatment had a favourable effect on the palpitation and angina pectoris also.
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