[利用富集的胶质细胞和神经元细胞组分研究老年人神经递质氨基酸转运的可能性]。

Voprosy biokhimii mozga Pub Date : 1978-01-01
G V Aprikian, V A Shaginian, G A Gevorkian, E S Akhverdian, A M Melikian
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引用次数: 0

摘要

以蛋白质为基础计算,从老年大鼠和成年大鼠的大脑中获得的神经元和胶质细胞富集部分的产量是相等的。老龄动物神经元部分对14C-GABA的高亲和力摄取减少了27.34%,胶质部分减少了11.87%。在0度时,两个年龄组的人对14C-GABA的摄取都受到了极大的抑制——神经元和神经胶质分别受到了66%和92%的抑制。结论:随着年龄的增长,神经胶质细胞的变化远小于神经元,因此其作为神经元功能调节剂的作用随着年龄的增长而增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Possibility of using enriched glial and neuronal cell fractions to study transport of neurotransmitter amino acids in old age].

Calculated on a protein basis the yield of neuronal and glial cell-enriched fractions obtained from the brain of aged and adult rats was found to be equal. In aged animals the high affinity uptake of 14C-GABA by neuronal fractions is reduced by 27.34% while that of glial fractions by 11.87%. At 0 degrees both age groups studied the uptake of 14C-GABA is greatly inhibited--by 66% in neurones and 92% in glia. The conclusion is drawn that glial cells are changed much less with age than neurones and thus their role as modulators of neuronal function increases with age.

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