{"title":"抗肿瘤药物顺式铂(en)Cl2与胞二酰-3′→5′-鸟苷的相互作用","authors":"J. Jordanov, R.J.P. Williams","doi":"10.1016/S0006-3061(00)80006-X","DOIUrl":null,"url":null,"abstract":"<div><p>Chemical shifts occurring in <sup>1</sup>H nuclear magnetic resonance and Sephadex G 25 chromatography are used to follow the reaction of the dinucleotide C3′p5′G (cytidilyl-3′phosphate5′-guanosine) in aqueous solution and to separate its products. Binding of the platinum occurs in first place at the cytosine, then at the guanine base. Two major complexes are produced, Pt:CpG and (Pt:CpG)<sub>2</sub>, which account for respectively for an internal and an external cross-linking effect.</p></div>","PeriodicalId":9177,"journal":{"name":"Bioinorganic chemistry","volume":"8 1","pages":"Pages 77-82"},"PeriodicalIF":0.0000,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80006-X","citationCount":"17","resultStr":"{\"title\":\"Interaction of the anti-tumour drug cis-Pt(en)Cl2 with cytidilyl-3′ → 5′-guanosine\",\"authors\":\"J. Jordanov, R.J.P. Williams\",\"doi\":\"10.1016/S0006-3061(00)80006-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Chemical shifts occurring in <sup>1</sup>H nuclear magnetic resonance and Sephadex G 25 chromatography are used to follow the reaction of the dinucleotide C3′p5′G (cytidilyl-3′phosphate5′-guanosine) in aqueous solution and to separate its products. Binding of the platinum occurs in first place at the cytosine, then at the guanine base. Two major complexes are produced, Pt:CpG and (Pt:CpG)<sub>2</sub>, which account for respectively for an internal and an external cross-linking effect.</p></div>\",\"PeriodicalId\":9177,\"journal\":{\"name\":\"Bioinorganic chemistry\",\"volume\":\"8 1\",\"pages\":\"Pages 77-82\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1978-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0006-3061(00)80006-X\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioinorganic chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S000630610080006X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinorganic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S000630610080006X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17
摘要
利用1H核磁共振和Sephadex G 25色谱发生的化学位移来跟踪二核苷酸C3'p5'G (cytidilyl-3 ' phosphate - 5 ' -guanosine)在水溶液中的反应并分离其产物。铂的结合首先发生在胞嘧啶上，然后在鸟嘌呤上。产生两种主要的配合物，Pt:CpG和(Pt:CpG)2，它们分别负责内部和外部交联效应。
Interaction of the anti-tumour drug cis-Pt(en)Cl2 with cytidilyl-3′ → 5′-guanosine
Chemical shifts occurring in 1H nuclear magnetic resonance and Sephadex G 25 chromatography are used to follow the reaction of the dinucleotide C3′p5′G (cytidilyl-3′phosphate5′-guanosine) in aqueous solution and to separate its products. Binding of the platinum occurs in first place at the cytosine, then at the guanine base. Two major complexes are produced, Pt:CpG and (Pt:CpG)2, which account for respectively for an internal and an external cross-linking effect.
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