先天性风疹致自闭症的随访报告。

S Chess
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引用次数: 374

摘要

对243例先天性风疹患儿进行了纵向研究。在这个样本中,观察到高孤独症率和高康复率。对资料的检查表明,风疹病毒是主要病原。假设自闭症的过程是一个慢性感染的过程,在这个过程中,自闭症综合症的恢复、慢性、改善、恶化和延迟出现都被发现。风疹的其他后果,如失明、耳聋、心脏和神经肌肉缺陷,除非通过手术和假体加以改善,否则仍然存在。智力发育迟缓的程度最初与自闭症的结果有关,但随着时间的推移,智力发育迟缓的变化与自闭症症状的变化没有显著的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Follow-up report on autism in congenital rubella.

A longitudinal study was conducted of 243 children with congenital rubella. In this sample a high rate of autism and a high rate of recovery were observed. Examination of the data suggested that the rubella virus was the primary etiologic agent. It is hypothesized that the course of autism was that of a chronic infection in which recovery, chronicity, improvement, worsening, and delayed appearance of the autistic syndrome all were found. Other rubella consequences such as blindness, deafness, and cardiac and neuromuscular defects remained present except as modified by operations and prostheses. Degree of mental retardation initially was related to the outcome of autism but shifts in mental retardation over time did not correlate significantly for the group with shift in the autistic symptoms.

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