ACTH是如何作用于大脑的

Adrian J. Dunn, Willem Hendrik Gispen
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引用次数: 85

摘要

ACTH似乎直接作用于大脑,调节某些行为并引发其他行为。本文综述了脑代谢对促肾上腺皮质激素的已知反应,试图阐明其行为活动的潜在机制。讨论了ACTH的脑定位及其对环AMP、RNA和蛋白质代谢以及对神经递质多巴胺、去甲肾上腺素、血清素和GABA的影响。在某些情况下,神经化学反应和行为反应之间存在相关性。讨论了促肾上腺皮质激素的潜在作用机制,并指出了今后的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
How ACTH acts on the brain

ACTH appears to act directly on the brain to modulate some behaviors and to elicit others. This paper reviews the known responses of cerebral metabolism to ACTH in an attempt to elucidate the underlying mechanism of its behavioral activity. The cerebral localization of ACTH and its effects on the metabolism of cyclic AMP, RNA and protein and on the neurotransmitters dopamine, norepinephrine, serotonin and GABA are discussed. In some cases there are correlations between the neurochemical and behavioral responses. Potential mechanisms of ACTH action are discussed and directions for future research indicated.

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