High-frequency enhanced based on high-resolution synthetic spectrum quantitative phase imaging

According to the phase gradient transfer function (PGTF) derived from the phase space theory, the phase recovery algorithm based on the transport of intensity equation (TIE) has the problem that the high-frequency phase is underestimated due to the coherence effect of the limited aperture system under partially coherent illumination. Therefore, based on the theory of PGTF and phase transfer function (PTF), a phase reconstruction algorithm named high-resolution synthetic spectrum (HSS) method combining the TIE and the PTF-based deconvolution is proposed. This technique broadens the application range and provides high contrast, high accuracy, and highresolution quantitative phase results with high robustness. The performances of this technology are demonstrated by simulation and experiments, showing efficient for phase retrieval in the near-Fresnel region. Such a highresolution method can offer a flexible and cost-effective alternative for biomedical research and cell analysis, providing new avenues to design powerful computational imaging systems