药物发现

Satyansh Singh, P. Yadav, Priyanshu Mishra, Asgar Shameem, Deepak Yadav
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引用次数: 0

摘要

由于研发和人体临床试验的高成本,药物开发过程是非常昂贵的过程。目前,人们正在尝试一种新的方法来了解疾病和感染是如何在分子和生理水平上控制的,并根据这些知识针对特定实体。药物的发现是基于分子生物学靶点,改善疾病的治疗,大剂量的化合物被引入细胞系或动物,以获得初步的疗效和药代动力学信息。药物发现的过程包括候选药物的鉴定、合成、表征、筛选和治疗效果的测定。一旦一种化合物在这些测试中显示出其价值,它将在临床试验之前开始药物开发过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Drug Discovery
The process of drug development is very expensive process due to high costs of R&D and human clinical tests. At present a new approach is being tried to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on the knowledge. The drugs discoveries are based on molecular biological targets and improve the therapy for disease, wide ranging dosages of the compounds are introduced to the cell line or animal in order to obtain preliminary efficacy and pharmacokinetic information. The process of drug discovery involves the identification of candidates, synthesis, characterization, screening & assay for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.
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