{"title":"复方铂治疗卵巢癌的增效作用","authors":"F. Huq, A. Alshehri, P. Beale, J. Q. Yu","doi":"10.1109/ICBPE.2009.5384108","DOIUrl":null,"url":null,"abstract":"The present study shows that combinations of cisplatin and YH12 produce sequence- and concentration-dependent synergism in human ovarian cancer cell lines A2780 and A2780cisR. Addition of YH12 followed by cisplatin 4 h later or addition of the two compounds at the same time produces synergism whereas the addition of cisplatin first followed by YH12 4 h later results into antagonism. If the results are found to be true in vivo, they may have profound implication in the design of combination therapy.","PeriodicalId":384086,"journal":{"name":"2009 International Conference on Biomedical and Pharmaceutical Engineering","volume":"180 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2009-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synergism from combination of platinums in ovarian cancer\",\"authors\":\"F. Huq, A. Alshehri, P. Beale, J. Q. Yu\",\"doi\":\"10.1109/ICBPE.2009.5384108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present study shows that combinations of cisplatin and YH12 produce sequence- and concentration-dependent synergism in human ovarian cancer cell lines A2780 and A2780cisR. Addition of YH12 followed by cisplatin 4 h later or addition of the two compounds at the same time produces synergism whereas the addition of cisplatin first followed by YH12 4 h later results into antagonism. If the results are found to be true in vivo, they may have profound implication in the design of combination therapy.\",\"PeriodicalId\":384086,\"journal\":{\"name\":\"2009 International Conference on Biomedical and Pharmaceutical Engineering\",\"volume\":\"180 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2009 International Conference on Biomedical and Pharmaceutical Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/ICBPE.2009.5384108\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2009 International Conference on Biomedical and Pharmaceutical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICBPE.2009.5384108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synergism from combination of platinums in ovarian cancer
The present study shows that combinations of cisplatin and YH12 produce sequence- and concentration-dependent synergism in human ovarian cancer cell lines A2780 and A2780cisR. Addition of YH12 followed by cisplatin 4 h later or addition of the two compounds at the same time produces synergism whereas the addition of cisplatin first followed by YH12 4 h later results into antagonism. If the results are found to be true in vivo, they may have profound implication in the design of combination therapy.
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