国产季铵盐杀菌剂在普通医学和牙科中的应用效果(现代观点与临床案例)

Yu. A. Bezhuk, Olesia Martovlos (Hodovana)
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引用次数: 0

摘要

十amethoxine (DCM®)是一类季铵盐化合物。根据文献资料,抗菌作用是由于一种机制,结合了对细菌细胞膜的破坏和原生质体的裂解,以及改变微生物细胞膜的通透性,导致其破坏。DCM®对革兰氏阳性和革兰氏阴性细菌(葡萄球菌、链球菌、白喉和大肠杆菌、沙门氏菌、变形杆菌、克雷伯氏菌、志贺氏菌、假单胞菌、梭菌)和一些真菌(酵母真菌、霉菌真菌)具有活性。也有报道说这种化合物具有抗病毒活性。本研究的目的是强调乌克兰科学家当前工作的结果,分析DCM®抗菌剂的特性和广泛方面,并展示其在牙周实践中的有效性的临床案例。对各种出版物结果的分析使我们能够全面评估DCM®在现代临床前和临床研究中的治疗潜力,特别是在牙周实践中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EFFECTIVENESS OF USING DOMESTIC QUATERNARY AMMONIUM ANTISEPTIC IN GENERAL MEDICINE AND DENTISTRY (MODERN VIEW AND CLINICAL CASE)
Decamethoxine (DCM®) is a substance from a group of quaternary ammonium compounds. According to literary sources, the antimicrobial effect is due to a mechanism that combines damage to the cell membrane of bacteria and lysis of their protoplasts, as well as changes the permeability of the microbial cell membrane, causing its destruction. DCM® demonstrates activity against gram-positive and gram-negative bacteria (staphylococci, streptococci, diphtheria and Escherichia coli, salmonella, proteus, klebsiella, shigella, pseudomonads, clostridia), some fungi (yeast fungi, mold fungi). There are also reports of the antiviral activity of this compound. The purpose of this study was to highlight the results of the current work of Ukrainian scientists and analyze the properties and broad aspects of DCM® antiseptic, as well as demonstrate their clinical case for its effectiveness in periodontal practice. The analysis of the results of various publications allowed us to evaluate the full range of DCM® properties in terms of its therapeutic potential in modern preclinical and clinical studies, particularly in periodontal practice.
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