铅离子对右心室心肌力学功能的影响

PHYSICS, TECHNOLOGIES AND INNOVATION (PTI-2019): Proceedings of the VI International Young Researchers’ Conference Pub Date : 2019-12-06 DOI:10.1063/1.5134322

O. Gerzen, I. Simanova, S. Nabiev, L. Nikitina, I. Selezneva

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引用次数: 1

摘要

以大鼠为模型，每周腹腔注射醋酸铅3次，连续5周。采用体外运动测定法测定了不同钙浓度下正常对照组和铅中毒组大鼠右心室肌球蛋白上细丝的运动速度。铅中毒使最大运动速度降低30%，这是由于肌球蛋白同型体向慢速移动，而对钙的调节没有影响。

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The influence of lead ions on the mechanical function of right ventricle myocardium

Lead intoxication was modelled by intraperitoneal injection of lead acetate to rats 3 times a week during 5 weeks. The velocity of thin filaments movement at different calcium concentrations over myosin extracted from the right ventricle of the rats’ hearts of control group and group with lead intoxication was estimated using an in vitro motility assay. Lead intoxication reduced the maximum velocity of movement by 30% because of the shift of myosin isoforms towards slow ones and did not influence on calcium regulation.

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PHYSICS, TECHNOLOGIES AND INNOVATION (PTI-2019): Proceedings of the VI International Young Researchers’ Conference

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