Hydrophobic Nanofibrous Materials for Prevention of Postoperative Tissue Adhesions

Undesirable tissue adhesions remain one of the severe and dreadful postoperative complications. The postoperative adhesions in abdominal cavity may often occur after the colorectal resection in case of colorectal cancer, Crohn disease or intestinal blockage. These postoperative complications may lead to chronic pain, female infertility, reoperation, decreased life quality and other serious complications [1], [2]. There are several attempts to understand the mechanism of formation of peritoneal adhesions. Moreover, significant effort was also put into development of a functional and safe material to prevent these complications. Despite the significant efforts, there is a lack of knowledge and available methods in this area [3]. The novel approach is to use a biocompatible barrier material, e.g. nanofibers, to the injured intestinal tissue and thus reduce the formation of peritoneal adhesions [1]. The planar nanofibrous materials can be applied around the surgical connection (gastrointestinal anastomoses) after the colorectal resection. To the best