Hand-in-glove effect of Piperine in anti-cancer formulations

Piperine, an active constituent isolated from Piper nigrum, Piper chaba, Piper sarmentosum, Piper guineense and Piper longum which is used to cure a variety of ailments related to lung, stomach, colon, skin etc. like Alzheimer’s, Parkinson’s disease, ulcerative colitis, cancer, arthritis, inflammatory bowel diseases, diabetes etc. The objective of the review is to study the synergistic effect of piperine specially in cancer. Patents and current literature mainly emphasizing the synergistic effect of piperine along with other drugs, especially anticancer drugs was reviewed keeping in mind the scientific novelty and impact. Several synergistic combinations of piperine were explored which can be beneficial for the pharmaceutical industry. This review will assist the researchers in the preparation of novel formulations with improved efficacy cutting the cost of developing new drug molecules.