{"title":"庆大霉素和奈替米星的肾毒性比较:功能和形态与尿酶活性的相关性。","authors":"R D Adelman, G Conzelman, W Spangler, G Ishizaki","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>An increase in urinary enzyme activities reflected biopsy confirmed aminoglycoside nephrotoxicity (proximal tubular injury) before changes in blood urea nitrogen, serum creatinine, urinary osmolality and urinary protein excretion. Netilmicin, a semisynthetic derivative of gentamicin, was less nephrotoxic than gentamicin.</p>","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":" 9","pages":"166-82"},"PeriodicalIF":0.0000,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative nephrotoxicity of gentamicin and netilmicin: functional and morphological correlations with urinary enzyme activities.\",\"authors\":\"R D Adelman, G Conzelman, W Spangler, G Ishizaki\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>An increase in urinary enzyme activities reflected biopsy confirmed aminoglycoside nephrotoxicity (proximal tubular injury) before changes in blood urea nitrogen, serum creatinine, urinary osmolality and urinary protein excretion. Netilmicin, a semisynthetic derivative of gentamicin, was less nephrotoxic than gentamicin.</p>\",\"PeriodicalId\":72742,\"journal\":{\"name\":\"Current problems in clinical biochemistry\",\"volume\":\" 9\",\"pages\":\"166-82\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1979-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current problems in clinical biochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current problems in clinical biochemistry","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparative nephrotoxicity of gentamicin and netilmicin: functional and morphological correlations with urinary enzyme activities.
An increase in urinary enzyme activities reflected biopsy confirmed aminoglycoside nephrotoxicity (proximal tubular injury) before changes in blood urea nitrogen, serum creatinine, urinary osmolality and urinary protein excretion. Netilmicin, a semisynthetic derivative of gentamicin, was less nephrotoxic than gentamicin.
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