Anaphylactic Reaction to Intraoperative Intravenous Mannitol: A Case Report

A 24 year old female, diagnosed with right middle cerebral artery aneurysm was posted for aneurysmal clipping. After uneventful induction of anaesthesia, on starting mannitol infusion patient developed high airway pressures within minutes. After ruling out common conditions, a diagnosis of anaphylactic reaction to mannitol was made. Surgery was postponed and after initial stabilization patient was shifted and managed in ICU. Although a rare entity, intraoperative anaphylactic reaction to mannitol should be kept in mind by anaesthesiologist.