五种卵巢癌基因表达数据集的meta分析和网络分析

2010 Third International Joint Conference on Computational Science and Optimization Pub Date : 2010-05-28 DOI:10.1109/CSO.2010.245

Hua Dong, Shengjun Hong, Xiaomin Xu, Yanghua Xiao, Li Jin, M. Xiong

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引用次数: 4

摘要

卵巢癌是妇女癌症死亡的第五大原因，也是妇科癌症死亡的主要原因。在此，我们对432例卵巢癌和42例相邻正常样本的5个基因表达数据集进行了荟萃分析。我们发现3个基因:NDN, RNASE4, IGFBP4在这5个数据集中有显著差异表达。对数据集进行meta分析后，有3722个基因显著(p值)

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Meta-analysis and Network Analysis of Five Ovarian Cancer Gene Expression Dataset

Ovarian cancer is the fifth leading cause of death from cancer in women and the leading cause of death from gynecological cancer. Here we present a meta-analysis of five gene expression data sets of 432 ovarian cancer and 42 adjacent normal samples in total. We indentified 3 genes: NDN, RNASE4, IGFBP4 were significantly differentially expressed in both five data sets. After combined the dataset by meta-analysis, 3722 genes were significant (p-value

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2010 Third International Joint Conference on Computational Science and Optimization

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