子宫内膜异位症不孕患者的流行病学概况

Renato de Oliveira, Deborah dos Santos Musich, Mariana Prince Santiago Fontes Ferreira, Fabia Lima Vilarino, Caio Parente Barbosa
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引用次数: 6

摘要

目的探讨子宫内膜异位症不孕患者的流行病学和临床特点。方法对2006年10月~ 2012年5月450例子宫内膜异位症不孕患者病历进行横断面分析。痛经、疼痛强度、肠道紊乱等症状,以及相关疾病和治疗方法。统计软件为Stata 11.0。结果中位年龄34岁。84.2%的患者出现痛经,40.4%的患者出现剧烈疼痛。肠道疾病占54.4%。从相关妇科疾病来看,有肌瘤的占23.3%。代谢性疾病占治疗疾病的8.4%。众所周知,痛经是患有子宫内膜异位症的女性最常见的症状,还有肠道疾病,在患有严重子宫内膜异位症的女性中,有6%到30%的人有痛经。其他研究表明,雌激素依赖性疾病和子宫内膜异位症与芳香化酶P450 CYP19突变有关;这就产生了一个雌激素分泌过多的环境,促进了息肉和肌瘤的发展。这些患者的情况被追踪到生命的第四个十年,主要是原发性不孕,普遍症状是严重痛经,并伴有息肉和肌瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Perfil epidemiológico das pacientes inférteis com endometriose

Aims

To describe epidemiological and clinical aspects of infertile patients with endometriosis.

Methods

Cross section study of 450 medical records of infertile patients with endometriosis from October, 2006 to May, 2012. Symptoms such as dysmenorrhea, pain intensity, intestinal disorders where analyzed, as well as, associated diseases and treatments. The statistical software used was Stata 11.0.

Results

The median age was 34 years. 84.2% of patients presented dysmenorrhea and 40.4% had severe pain intensity. Intestinal disorders was found in 54.4%. From the associated gynecologic diseases, 23.3% had myoma. Metabolic disease was found in 8.4% among the diseases in treatment.

Discussion

It is known that dysmenorrhea is the most prevalent symptom in women with endometriosis, as well as intestinal disorders, that can be found between 6% and 30% women with severe endometriosis. Other studies have demonstrated the relationship of estrogen‐dependent disease and women with endometrial endometriosis with aromatase enzyme P450 CYP19 mutations; which generate a hyperestrogenic environment, contributing to the development of polyps and myomas. The profile of these patients was traced as being in the fourth decade of life, with predominantly primary infertility with prevalent symptoms of severe dysmenorrhea and association with polyps and myomas.

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