基因调控网络的解析解

E. Gelenbe
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引用次数: 3

摘要

我们研究基因调控网络,包括多重二元相互作用的影响,当各种基因可以激活或抑制其他基因时,以及三元相互作用,其中两个基因共同影响第三个基因的活性水平。我们还证明了根据另一组基因的激活水平来表示基因激活状态的布尔身份,从而可以在存在逻辑依赖性和基因之间的兴奋-抑制相互作用的情况下计算网络中任何基因激活的总体概率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analytical Solution of Gene Regulatory Networks
We study gene regulatory networks that include the effect of multiple binary interactions, when various genes can activate or inhibit other genes, as well as of ternary interactions where two genes jointly affect the level of activity of a third gene. We also prove that Boolean identities for the activation state of a gene in terms of the activation level of another set of genes, can be represented, so that the overall probability of activation of any gene in the network can be computed in the presence of logical dependencies, and excitatory-inhibitory interactions between genes.
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