Assessment of immunohistochemical Expression of HER2\Neu and BRCA1 in Colorectal Tumors and it's Correlation with Clinicopathological Variables

: Background: HER2\neu and BRCA1 expression in tumors is consider as a important prognostic marker in relation to the use of adjuvant therapy specially in a patients with worse prognosis in which that result in improvement in their survival. this research was done to assess the HER2\neu and BRCA1 immunohistochemical expression in colorectal tumors in correlation with some clinicopathological parameters. Methods: in this study(which was done retrospectively), A 44 cases include22 benign colonic lesions and 22 colonic adenocarcinoma in addition 6 normal resection (non tumors) margin were used as a control group, paraffin embedded archival materials from this cases were collected for the period between Nov 2015- July 2016.the expression of 2 markers (HER2/neu and BRCA1)were assessed and then were correlated with different clinicopathological parameters . Results: the immunohistochemical expression of HER2\neu was (45%) of CRC, in (27%) of colorectal polyps and in (4) out of (6) non-neoplastic colonic tissues. the in in the age of more 40 , in well differentiated adenocarcinoma (67%), in non mucinous adenocarcinoma (90%), in T2 (54%) and the tumor size of more than 4 cm although the results were statistically not significant..