Chandramani, Vaishali Mishra, S. Chauhan, Manish Kumar Gupta
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Molecular interaction and simulation analysis for thyroid cancer pathway
The most common cancer of endocrine gland is thyroid cancer. TSH binds with TSHR and activates different signaling pathways. MAPK is the most occurring pathways, it potentially activates the TG gene expression. p53, Wnt and Apoptosis increase the TG gene expression and injury in thyroid gland. Commonly occurring form of thyroid cancer is papillary thyroid carcinoma (PTC). This study predicts several therapeutic targets in different pathways. In this paper four molecular interaction map viz MAPK, p53, Wnt and Apoptosis pathways were taken for study which probably regulates uncontrolled cell division and thyroid hormone synthesis pathways.
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