地高辛使用的当前考虑。

W Shapiro
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引用次数: 1

摘要

在生物转化和药效学方面的基本考虑是理解临床使用的基础。极性在决定给定糖苷的作用时间和生物转化程度中的作用被强调。总结了地高辛的药代动力学,强调口服地高辛不能完全吸收。本文综述了地高辛血清水平与心肌含量以及心肌反应之间的重要关系。这种关系和地高辛血清中精确测量方法的发展为临床医生在不同临床情况下评估地高辛心肌耐受性提供了准确的手段。本文综述了数字化方法、正确使用血清水平、地高辛表观和真实耐药性以及地高辛表观和真实敏感性的讨论。分析了血清水平作为毒性精确指南的局限性。最后,介绍了地高辛中毒免疫治疗的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current considerations in digoxin usage.

Basic considerations in biotransformation and pharmacodynamics are presented as a basis for understanding clinical usage. The role of polarity in determining a given glycoside's duration of action and extent of biotransformation is emphasized. The pharmacokinetics are summarized emphasizing the fact that digoxin is not completely absorbed by oral administration. The important relationship of serum digoxin levels to myocardial content and apparently to myocardial response is reviewed. This relationship and the development of precise methods for measurement of digoxin in serum provide the clinician with accurate means to assess myocardial tolerance for digoxin under diverse clinical circumstances. This review includes discussion of methods of digitalization, appropriate use of serum levels, apparent and real resistance to digoxin, and apparent and real sensitivity to digoxin. The limitations of serum levels as a precise guide to toxicity are analyzed. Finally, new developments in use of immunologic therapy for digoxin intoxication are presented.

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