异源移植和基因组学在癌症研究中的应用

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引用次数: 0

摘要

1975年,我们首次在裸鼠身上进行了无脊椎A.O异体移植,随后在裸鼠身上进行了人类肿瘤和轴向器官的双异体移植,观察到的病例中,50%的人肿瘤被排斥。几年后,我们发现A.O细胞对SP2和MBL2小鼠肿瘤细胞具有诱导和自发的细胞毒性。最近,我们发现了一种具有免疫特性的海星Igkappa基因。该基因被插入巨细胞病毒(CMV),最后被插入名为“年轻”质粒的质粒。诱导的“年轻”蛋白对骨肉瘤细胞(u20s细胞)、a -375黑色素细胞和Hela细胞具有自发的细胞毒性
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HETEROTRANSPLANTATIONS AND GENOMIC IN CANCER RESEARCH
We performed ,in 1975, the first heterotransplantation of invertebrate A.O in nude mouse, then a double heterotransplantation of human tumor and Axial organ next to this last one, always in nude mouse: The human tumor was rejected in 50% of observed cases. Some years later, we found that A.O cells exerted an induced and spontaneous cytotoxicity against SP2 and MBL2 mouse tumoral cells. Recently, we discovered a sea star Igkappa gene with immune properties. This gene was inserted in a CMV(cytomegalovirus) and finally in a plasmid called « young » plasmid. The induced« young » protein exerted a spontaneous cytotoxicity against osteosarcom cells (U2oS cells) against A-375 melanome cells and Hela cells
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