[黄曲霉毒素的生化活性(作者译)]。

Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Betriebshygiene, praventive Medizin Pub Date : 1978-12-01

J Reiss

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引用次数: 0

摘要

鼠伤寒沙门菌-肝微粒体技术实验结果表明，黄曲霉毒素B1的致突变致癌代谢物为黄曲霉毒素B1- 1,2,3-氧化物。这种化合物在DNA中与鸟嘌呤形成加合物。不同黄曲霉毒素衍生物的致突变活性与致癌性密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[The biochemical activity of the aflatoxins (author's transl)].

Results of experiments with the Salmonella typhimurium-liver microsome technique make it evident that the mutagenic and carcinogenic metabolite of aflatoxin B1 is aflatoxin B1-2,3-oxide. This compound forms adducts with guanine in DNA. There is a close relationship between the mutagenic activity and the hepatocarcinogenic property of the different aflatoxin derivatives.

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Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, Betriebshygiene, praventive Medizin

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