We have never been Only Human: The Inescapable Multiomics of our Existence

This editorial urges a paradigm shift in our understanding of human health and disease, proposing that we are not merely human, but exist as part of a dynamic multiomic system. Traditional binary perceptions of disease - as present or absent - are critiqued, and the urgency to embrace a new approach is underscored. By viewing disease as a spectrum of states stemming from variations across genomics, transcriptomics, proteomics, and environmental influences, we can revolutionize our approach to healthcare. The editorial underscores the vital role of artificial intelligence in synthesizing and analyzing vast data sets, providing a comprehensive and dynamic view of disease. It emphasizes the necessity to orient current research towards this multiomic perspective, asserting that this approach is integral to transcending our existing limitations in disease understanding and management. This call for a new perspective offers potential for more predictive, preventive, and personalized healthcare, promising to bring about significant advancements in our fight against disease.