Efficiency of brinzolamide and its combinations with timolol maleate in the treatment of primary open-angle glaucoma

PURPOSE. To evaluate the effectiveness of 1% brinzolamide solution (Brineks-M) and its combination with 0.5% timolol maleate solution (Brinarga) in the treatment of patients with primary open-angle glaucoma (POAG).METHODS. The study involved 56 patients (56 eyes) with initial or moderate POAG and normal or moderately increased intraocular pressure. Individually tolerated IOP, hydrodynamic parameters, hemodynamic parameters of the eye (by computer ophthalmoplethysmography), microcirculation (by OCT angiography of the optic nerve head) were determined during the study.RESULTS. The hypotensive effect of 1% brinzolamide solution (Brineks-M) in patients with the early stage of POAG (23 eyes) after 3 months was 22.5%. The antihypertensive effect of Brinarga in patients with early and moderate stages of POAG (33 eyes) was 31.3% and persisted for 3 months of observation.CONCLUSION. A decrease in IOP to an individually tolerable level was accompanied by an improvement in ocular hemodynamics and microhemocirculation of the optic nerve head, and stabilization of visual functions in patients with POAG.