赋形剂在液固技术中的作用

Shaveta Sharma
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引用次数: 0

摘要

本文给出了液固工艺中辅料的选择标准。液固技术是将药物溶液转化为干燥、自由流动的粉末,适用于非极性药物。许多技术如固体分散、微粉化、冻干共磨、共沉淀、络合和纳米技术被用于提高水溶解度。固体分散有稳定性问题,而微粉化和络合会导致团聚。在纳米技术中,高成本涉及到复杂的仪器。液体固体技术被认为是克服溶解度、溶解性和生物利用度的最佳技术之一。它将药物溶液转化为干燥的自由流动的粉末。该工艺制造工艺简单,生产成本低。使用该技术可提高体外释放。在此过程中,赋形剂对药物的有效释放起着重要的作用。BCS II类和IV类的相关问题主要解决在溶解度方面。特别是具有高比表面积的载体在克服各种挑战方面取得了很好的效果。载体如乳糖、淀粉、Avicel pH101、Fujacilin、Neusilin等,每一种都有特定的药物释放特性。在所有的载体中,使用最多的是Avicel、Fujacilin和Neusilin,它们的比表面积(SSA)最高。聚乙烯吡咯烷醚具有良好的溶胀性和流动性,可用于大剂量药物,被认为是最佳崩解剂。Neusilin、Aerosil、PVP作为载体、包衣材料和崩解剂被认为是液固技术中理想的辅料,具有较大的SSA和较高的吸附性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Excipients in Liquisolid Technology
This article gives criteria for choosing excipients in liquisolid technology. Liquisolid technology is applicable for non polar drugs by converting drug solution into dry free flowing powder. Patient compliance is more in oral route of administration .Numerous techniques like solid dispersion, micronisation, lyophilisation co-grinding, co-precipitation,complexation and nanotechnology are used to increase aqueous solubility Solid dispersion having stability issues while micronization and complexation can cause agglomeration. In Nanotechnology, high cost involved in sophicticated instruments. Liquisolid technology is considered to be one of the best technique to to overcome solubility,dissolution and bioavailability. It convert drug solution into dry free flowing powder. This technique is simple manufacturing process with low production cost. In vitro release is enhanced by using this technology. There is significant role of excipients in this novel technique to get effective release of drug. Associated problems of BCS class II and IV is mostly solved in respect to solubility. Especially carrier with high specific surface area gives good results in overcoming all challenges. Carriers such as Lactose, Starch, Avicel pH101,Fujacilin, Neusilin ,each having specific properties in release of drug. Among all mostly used carriers are Avicel, Fujacilin and Neusilin as with highest Specific Surface Area (SSA) than others. PVP and SSG is considered best disintegrating agent as having good swelling property and flow property as Polyvinypyrrolidine can be used in high dose drugs. With large SSA and high adsorptive property Neusilin, Aerosil , PVP as carrier, coating material and disintegrating agent are considered perfect excipients in liquisolid technology.
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