B. Šošić-Jurjević, B. Filipović, N. Nestorović, M. Lovren, M. Sekulić
{"title":"钙对中年雌性大鼠甲状腺组织结构和形态特征的影响","authors":"B. Šošić-Jurjević, B. Filipović, N. Nestorović, M. Lovren, M. Sekulić","doi":"10.2298/JMH0203261S","DOIUrl":null,"url":null,"abstract":"The aim of the present work was to study the effect of Ca supplementation therapy on structural and morphological features of the thyroid gland tissue in middle-aged female rats. Some of the findings described herein have been previously presented in an abstract form (10). Summary: The subject of these studies was the thyroid gland tissue of middle-aged (14-month-old) female rats chronically treated with calcium glucoheptonate. The peripheral and central zone of the thyroids were stere- ologically analysed and the following morphometric parameters determined: the height and volumetric density of follicular epithelium, colloid, interstitium and follicles and index of activation rate. The height of follicular epithelium, its volume density and index of activation rate were significantly reduced (by 8%, p < 0.05, 18%, p< 0.025 and 34%, p < 0.01, respectively) as compared to the controls. However, the volumetric density of colloid and interstitium were increased (by 10% and 14% respectively). These morphometric results indicate that Ca treatment expressed an inhibitory effect on thyroid follicular cells structure in middle-aged female rats.","PeriodicalId":287983,"journal":{"name":"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry","volume":"14 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"EFFECT OF CALCIUM ON STRUCTURAL AND MORPHOMETRIC FEATURES OF THYROID GLAND TISSUE IN MIDDLE-AGED RAT FEMALES\",\"authors\":\"B. Šošić-Jurjević, B. Filipović, N. Nestorović, M. Lovren, M. Sekulić\",\"doi\":\"10.2298/JMH0203261S\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of the present work was to study the effect of Ca supplementation therapy on structural and morphological features of the thyroid gland tissue in middle-aged female rats. Some of the findings described herein have been previously presented in an abstract form (10). Summary: The subject of these studies was the thyroid gland tissue of middle-aged (14-month-old) female rats chronically treated with calcium glucoheptonate. The peripheral and central zone of the thyroids were stere- ologically analysed and the following morphometric parameters determined: the height and volumetric density of follicular epithelium, colloid, interstitium and follicles and index of activation rate. The height of follicular epithelium, its volume density and index of activation rate were significantly reduced (by 8%, p < 0.05, 18%, p< 0.025 and 34%, p < 0.01, respectively) as compared to the controls. However, the volumetric density of colloid and interstitium were increased (by 10% and 14% respectively). These morphometric results indicate that Ca treatment expressed an inhibitory effect on thyroid follicular cells structure in middle-aged female rats.\",\"PeriodicalId\":287983,\"journal\":{\"name\":\"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry\",\"volume\":\"14 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2298/JMH0203261S\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2298/JMH0203261S","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
EFFECT OF CALCIUM ON STRUCTURAL AND MORPHOMETRIC FEATURES OF THYROID GLAND TISSUE IN MIDDLE-AGED RAT FEMALES
The aim of the present work was to study the effect of Ca supplementation therapy on structural and morphological features of the thyroid gland tissue in middle-aged female rats. Some of the findings described herein have been previously presented in an abstract form (10). Summary: The subject of these studies was the thyroid gland tissue of middle-aged (14-month-old) female rats chronically treated with calcium glucoheptonate. The peripheral and central zone of the thyroids were stere- ologically analysed and the following morphometric parameters determined: the height and volumetric density of follicular epithelium, colloid, interstitium and follicles and index of activation rate. The height of follicular epithelium, its volume density and index of activation rate were significantly reduced (by 8%, p < 0.05, 18%, p< 0.025 and 34%, p < 0.01, respectively) as compared to the controls. However, the volumetric density of colloid and interstitium were increased (by 10% and 14% respectively). These morphometric results indicate that Ca treatment expressed an inhibitory effect on thyroid follicular cells structure in middle-aged female rats.
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