不溶性血小板膜可能是有效和安全的:一个小回顾

S. Nasiri
{"title":"不溶性血小板膜可能是有效和安全的:一个小回顾","authors":"S. Nasiri","doi":"10.26420/THROMBHAEMOSTRES.2019.1021","DOIUrl":null,"url":null,"abstract":"Our recent experiences have shown that major platelet adhesion (CD41b) and aggregation (CD41/CD61) receptors presence on the membrane with platelet factor 3 activity in lyophilized IPM preparation [18]. As well, our newer animal studies of IPM have demonstrated its efficacy with dose-dependent property [19,20], without any pyrogenic side effect [21] or toxicity [22]. Nasiri et al results in rabbits showed that the maximum hemostatic effectiveness was at 2 hours after IPM administration, while Chao et al had been reported 4 hours [11]. Also, the major aggregation receptor of platelets CD41/CD61 was present on our IPM, but was absent in Chao experiment may be due to our modified IPM processing with lower detrimental effects on platelet membrane receptors. These findings confirms more improving of its hemostatic effectiveness.","PeriodicalId":219286,"journal":{"name":"Austin Thrombosis reasearch and Treatment","volume":"28 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Infusible Platelet Membrane may be Effective and Safe: A Mini Review\",\"authors\":\"S. Nasiri\",\"doi\":\"10.26420/THROMBHAEMOSTRES.2019.1021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Our recent experiences have shown that major platelet adhesion (CD41b) and aggregation (CD41/CD61) receptors presence on the membrane with platelet factor 3 activity in lyophilized IPM preparation [18]. As well, our newer animal studies of IPM have demonstrated its efficacy with dose-dependent property [19,20], without any pyrogenic side effect [21] or toxicity [22]. Nasiri et al results in rabbits showed that the maximum hemostatic effectiveness was at 2 hours after IPM administration, while Chao et al had been reported 4 hours [11]. Also, the major aggregation receptor of platelets CD41/CD61 was present on our IPM, but was absent in Chao experiment may be due to our modified IPM processing with lower detrimental effects on platelet membrane receptors. These findings confirms more improving of its hemostatic effectiveness.\",\"PeriodicalId\":219286,\"journal\":{\"name\":\"Austin Thrombosis reasearch and Treatment\",\"volume\":\"28 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Austin Thrombosis reasearch and Treatment\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26420/THROMBHAEMOSTRES.2019.1021\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Austin Thrombosis reasearch and Treatment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26420/THROMBHAEMOSTRES.2019.1021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

我们最近的经验表明,在冻干IPM制剂[18]中,主要的血小板粘附(CD41b)和聚集(CD41/CD61)受体存在于具有血小板因子3活性的膜上。此外,我们最新的IPM动物实验也证明了其具有剂量依赖性的功效[19,20],没有任何热原性副作用[21]或毒性[22]。Nasiri等人的家兔实验结果显示,IPM给药后2小时止血效果最大,而Chao等人的研究结果为4小时。此外,我们的IPM中存在主要的血小板聚集受体CD41/CD61,但在Chao实验中不存在,这可能是由于我们改进的IPM处理对血小板膜受体的有害影响较小。这些发现证实了其止血效果的进一步改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Infusible Platelet Membrane may be Effective and Safe: A Mini Review
Our recent experiences have shown that major platelet adhesion (CD41b) and aggregation (CD41/CD61) receptors presence on the membrane with platelet factor 3 activity in lyophilized IPM preparation [18]. As well, our newer animal studies of IPM have demonstrated its efficacy with dose-dependent property [19,20], without any pyrogenic side effect [21] or toxicity [22]. Nasiri et al results in rabbits showed that the maximum hemostatic effectiveness was at 2 hours after IPM administration, while Chao et al had been reported 4 hours [11]. Also, the major aggregation receptor of platelets CD41/CD61 was present on our IPM, but was absent in Chao experiment may be due to our modified IPM processing with lower detrimental effects on platelet membrane receptors. These findings confirms more improving of its hemostatic effectiveness.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信